Correlation between related inflammation indicators and the degree of liver fibrosis in patients with chronic hepatitis B

This study aims to investigate the values of related inflammation indicators in predicting the degree of liver fibrosis in patients with chronic hepatitis B (CHB). A 1-year retrospective study was conducted. The 120 CHB patients in the case group were divided into the non-fibrosis group (n = 26), mild-moderate fibrosis group (n = 34), severe fibrosis group (n = 27), and cirrhosis group (n = 33) based on the results of liver transient elastography. A total of 28 healthy individuals were included in the control group. Systemic immune inflammation index (SII), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio, and monocyte-to-lymphocyte ratio were observed and compared. There was a significant correlation between liver fibrosis and SII, NLR, and PLR (P < .001), with the strongest correlation between liver fibrosis and SII (r = -0.952). With an area under the receiver operating characteristic curve of 0.982, an SII ≤ 353.605 had the best sensitivity accuracy (97.9%) for the detection of any grade of liver fibrosis. The 5 combined indicators had the highest specificity accuracy (96.2%). In limited-resource settings, the SII could serve as a new strategy for predicting the degree of liver fibrosis in CHB patients and was superior to the PLR and NLR.