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September 10, 2025PROTEOMICSOpen Access

Dynamic Proteome Landscape During Preimplantation Human Embryo Development and Trophectoderm Stem Cell‐Differentiation

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Authors

ARAlin RaiQPQi Hui PohHOHiroaki Okae

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Overview

Quantitative proteomic analysis reveals protein expression changes during embryo development and trophoblast differentiation.

Key Points

  • Dynamic protein expression varies significantly between M2, 8-cell embryos, and blastocyst stages, enhancing our understanding of embryogenesis.
  • A total of 156 proteins were linked to the critical transition from 8-cell embryos to blastocyst development, highlighting metabolic networks.
  • Quantitative mass spectrometry analysis facilitated the systematic monitoring of protein expression in the preimplantation human embryo development.
  • These findings are pivotal for further mechanistic studies on human trophoblast function and early embryonic development.

Cite This Study

Rai et al. (2025) studied this question.

synapsesocial.com/papers/68c1a8fe54b1d3bfb60e1cd1https://doi.org/10.1002/pmic.70017
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An Integrated Proteomics and Genomics Approach to Identify Essential Protein Kinases During Human Trophoblast Development2026
  2. 2Proteome asymmetry in mouse and human embryos before fate specification2024 · 2 citations
  3. 3A prospective study of the proteome of equine pre‐implantation embryo2024
  4. 4Mitochondria-Associated Transcription Precedes Oxidative Phosphorylation in Human Embryos2026
  5. 5Single-cell proteomics of pre-implantation mouse embryos uncovers distinct asymmetry of certain proteins among early blastomeres2024