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September 10, 2025HLA

NK Alloreactivity Evaluation According to KIR‐HLA Interaction Models Influences the Outcome of Haploidentical Haematopoietic Stem‐Cell Transplantation Based on Post‐Transplant Cyclophosphamide

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Authors

JRJairo Eduardo Niño RamírezUniversidad de Salamanca FGFrancisco Javier Gil‐EtayoUniversidad de Salamanca MSMarta Fonseca SantosUniversidad de Salamanca

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Implication

Observational analysis reveals the role of NK alloreactivity and KIR-HLA interactions in haplo-HSCT outcomes, suggesting improvements in donor selection.

Key Points

NK alloreactivity significantly influences outcomes in haploidentical haematopoietic stem-cell transplantation.
Presence of at least two iKIR mismatches was an independent risk factor for severe acute graft-versus-host disease.
Models based on KIR-HLA interactions accurately predicted transplant outcomes compared to others.
Incorporating NK alloreactivity into the donor selection algorithm may enhance haplo-HSCT success rates.

Cite This Study

Ramírez et al. (2025) studied this question.

synapsesocial.com/papers/68c1a8fe54b1d3bfb60e1d28 https://doi.org/10.1111/tan.70340

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Implication

Observational analysis reveals the role of NK alloreactivity and KIR-HLA interactions in haplo-HSCT outcomes, suggesting improvements in donor selection.

NK Alloreactivity Evaluation According to KIR‐HLA Interaction Models Influences the Outcome of Haploidentical Haematopoietic Stem‐Cell Transplantation Based on Post‐Transplant Cyclophosphamide

Discussion

Member takes

Implication

Key Points

Cite This Study

NK Alloreactivity Evaluation According to KIR‐HLA Interaction Models Influences the Outcome of Haploidentical Haematopoietic Stem‐Cell Transplantation Based on Post‐Transplant Cyclophosphamide

Discussion

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Implication

Key Points

Cite This Study

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