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September 10, 2025Nanotoxicology

A meticulous biocompatibility and toxicological assessment of a self-assembling peptide nanofiber-nanoceramic biomimetic nanocomposite, per ISO 10993 guidelines

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Authors

SCSolmaz ChegeniHTHani TavakolSRSeyed Mahdi Rezayat

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Overview

This analysis measures biocompatibility and safety of a self-assembling peptide nanocomposite, adhering to ISO 10993 guidelines and revealing significant osteogenic properties.

Key Points

  • The nanocomposite demonstrated excellent biocompatibility, showing no significant reduction in cell viability.
  • Genotoxicity tests revealed no DNA damage, while hemocompatibility showed acceptable hemolytic activity.
  • Systemic toxicity studies in mice indicated no adverse clinical signs or organ pathologies after testing.
  • Bone regeneration in rabbits showed complete osteoinductive potential over one month, confirming the nanocomposite's effectiveness.

Cite This Study

Chegeni et al. (2025) studied this question.

synapsesocial.com/papers/68c1a90554b1d3bfb60e20e4https://doi.org/10.1080/17435390.2025.2538479
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