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September 10, 2025ACS Applied Materials & Interfaces

Biomimetic Nanoparticles with Dual Targeting for Hepatocellular Carcinoma Promote Tumor Immune System Activation by Enhancing Extracellular ATP Homeostasis

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JLJianwei LanTianjin Medical University General Hospital XCXu ChuPeking University LXLonghui XieHunan University of Science and Engineering

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This research demonstrates that biomimetic nanoparticles improve antitumor immunity in hepatocellular carcinoma, highlighting the role of extracellular ATP and targeting myeloid-derived suppressor cells.

Key Points

Biomimetic nanoparticles significantly promote antitumor immunity by enhancing extracellular ATP levels.
The key effect includes targeting myeloid-derived suppressor cells and inhibiting their immunosuppressive functions.
These nanoparticles facilitate a chemodynamic therapy approach, effectively inducing immunogenic cell death in cancer cells.
This dual targeting strategy shows promise as a new therapeutic alternative for patients with hepatocellular carcinoma.

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Lan et al. (2025) studied this question.

synapsesocial.com/papers/68c1a90c54b1d3bfb60e224e https://doi.org/10.1021/acsami.5c04278

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Biomimetic Nanoparticles with Dual Targeting for Hepatocellular Carcinoma Promote Tumor Immune System Activation by Enhancing Extracellular ATP Homeostasis

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Key Points

Cite This Study

Biomimetic Nanoparticles with Dual Targeting for Hepatocellular Carcinoma Promote Tumor Immune System Activation by Enhancing Extracellular ATP Homeostasis

Discussion

Member takes

Implication

Key Points

Cite This Study

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