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September 10, 2025Pharmaceuticals0 citationsOpen Access

SZC-6 Enhances Diabetic Wound Healing by Modulating Macrophage Polarization and Inflammatory Pathways

SZC-6 Promotes Diabetic Wound Healing in Mice by Modulating the M1/M2 Macrophage Ratio and Inhibiting the MyD88/NF-χB Pathway

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Authors

ADAnh Tuan Dinh‐XuanMLMeng LiuLZLingli Zhang

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Overview

In vivo experiments highlighted SZC-6's role in improving wound healing in diabetic mice, suggesting it may target macrophages and inflammatory pathways.

Key Points

  • SZC-6 treatment accelerated wound healing in diabetic mice, enhancing recovery processes.
  • In vivo analysis showed increased M2 macrophages and decreased M1 macrophages, indicating a shift in polarization.
  • The compound down-regulated inflammatory factors and preserved mitochondrial homeostasis during treatment.
  • SZC-6 inhibited the MyD88/NF-χB pathway, reducing inflammation associated with diabetic ulcers.

Cite This Study

Dinh‐Xuan et al. (2025) studied this question.

synapsesocial.com/papers/68c1a91354b1d3bfb60e2586https://doi.org/10.3390/ph18081143
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Also Consider

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