Drug therapy of the open pyometra in dogs: a comparative assessment of the effectiveness of “Estrophanthin” in monotherapy and in combination with “Alizine”

Relevance . Pyometra is a common and potentially life–threatening pathology of the uterus in dogs. Panovariohysterectomy with systemic antibiotic therapy is recognized as the main method of treating pyometra in dogs. An organ-preserving approach in young and valuable breeding animals is provided by the drug treatment of bitches with an uncomplicated form of the disease. Methods . The study was conducted on dogs with an open pyometra, divided into 2 comparable groups according to the scheme of drug therapy: I group consisted of sick dogs (n = 6) who received “Estrophanthin®” (a. s. cloprostenol), II group — sick dogs (n = 6) who received the antigestagenic drug “Estrophanthin®” along with “Alizine®” (a. s. aglepriston). Systemic antibiotic therapy was also used in both groups. The diagnosis on the pyometer was made collectively, based on the data of anamnesis, clinical and gynecological examination, transabdominal ultrasound (ultrasound) of the internal genitalia, ultrasound Dopplerography (ultrasound) of the uterine vessels and the results of clinical and biochemical blood tests. Results . During a comprehensive clinical and echographic examination of experimental dogs on days 21–28 of the experiment, complete remission of pyometra symptoms in the combination therapy group was 100% (versus 66.67% in the “Estrophantine” monotherapy group). Recovery of sexual cyclicity was noted in the group of combined prostaglandin-antigestogen therapy (II group) by 33.3% higher (83.3% versus 50.0%) than with Estrophantine monotherapy (I group). Pyometra recurrence was recorded in I group in only one dog (16.67%), whereas in II group the frequency of pyometra recurrence was twice as high and amounted to 33.33%.