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September 10, 2025Frontiers in Molecular BiosciencesOpen Access

A comprehensive analysis of the tryptophan metabolism-related gene signature to predict the prognosis of esophageal squamous cell carcinoma based on multi-omics

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Authors

ZWZhengjie WuShandong UniversityZLZhiping LiuGuangxi Normal UniversityYWYukun WangQingdao University

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Implication

Analysis reveals five-gene tryptophan signature associated with prognosis in esophageal squamous cell carcinoma, highlighting immune infiltration and treatment sensitivity.

Key Points

  • High-risk patients had poorer overall survival, indicating the role of tryptophan metabolism in esophageal squamous cell carcinoma.
  • Five significant tryptophan-related genes were identified as prognostic factors, with notable downregulation in tumor samples.
  • Single-cell RNA sequencing integrated with proteomics data enabled detailed exploration of tumor microenvironment interactions.
  • A predictive nomogram was developed using independent prognostic factors, enhancing prognosis prediction accuracy in esophageal squamous cell carcinoma.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/68c1a91354b1d3bfb60e271fhttps://doi.org/10.3389/fmolb.2025.1613539
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