Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Cell Death and DiseaseOpen Access

METTL5 regulates SEPHS2-mediated selenoprotein synthesis to promote multiple myeloma survival and progression

View Full Paper
Ask AI
Bookmark
Share

Authors

JJJing JiangQingdao University of Science and TechnologyFZFangmin ZhongNanchang UniversityZXZuomiao XiaoNanchang University

Discussion

Loading...

Member takes

Overview

Study demonstrates METTL5 regulates translation efficiency and SEPHS2 in multiple myeloma, suggesting potential therapeutic strategies.

Key Points

  • Elevated METTL5 expression in multiple myeloma patients correlates with poorer prognosis and survival.
  • Depletion of METTL5 results in decreased translation efficiency and diminished SEPHS2 levels, which impacts selenoprotein synthesis.
  • SAC exhibits significant pro-apoptotic effects in multiple myeloma both in vitro and in vivo.
  • The study highlights METTL5's critical role in promoting multiple myeloma cell survival through selenium metabolism regulation.

Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/68c1aab854b1d3bfb60e29cehttps://doi.org/10.1038/s41419-025-07904-6
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 15′UTR G-quadruplex structure enhances translation in size dependent manner2024 · 49 citations
  2. 2The Potential of Selenium-Based Therapies for Ocular Oxidative Stress2024 · 21 citations
  3. 3METTL5 promotes gastric cancer progression via sphingomyelin metabolism2024 · 8 citations
  4. 4Mezigdomide and Multiple Myeloma2023 · 12 citations
  5. 5Antitumor Effects of Selenium2021 · 110 citations