Review highlights ketamine's mechanisms and clinical data in substance use disorders, suggesting effective integration with psychotherapy.
Substance use disorders (SUDs) are notoriously difficult to treat due to complex biopsychosocial underpinnings and high relapse rates. Recent evidence positions ketamine-assisted psychotherapy (KAP) as a promising intervention for treatment-resistant addiction. This review explores ketamine’s neurobiological mechanisms, its synergistic effect with psychotherapy, and clinical data supporting its efficacy in various substance use disorders. Additionally, it addresses safety concerns and outlines practical considerations for integration into clinical practice.
No takes yet. Share an insight, caveat, or question.
Ryan D. Ward (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: