THE EFFECT OF Lactobacillus plantarum IS-10506 IN EXCESSIVE RESPIRATORY TRACT INFLAMMATION FOLLOWING SMOKE INHALATION

Background. Smoke inhalation induces injury to the respiratory tract and lung parenchyma through exposure to smoke and toxic chemicals. Lactobacillus plantarum IS-10506 has been reported to exert anti-inflammatory effects on the respiratory system. This study aimed to evaluate the efficacy of Lactobacillus plantarum IS-10506 in attenuating respiratory tract inflammation following smoke exposure. Methods. Sixteen BALB/c mice were exposed to cotton smoke and randomized into two groups: a control group (no probiotic treatment) and a treatment group receiving Lactobacillus plantarum IS-10506. Neutrophil counts in bronchoalveolar lavage fluid were measured, and lung histopathology was evaluated to assess inflammation. Results. The treatment group demonstrated lower median inflammation scores and neutrophil counts compared to the control group. However, these differences were not statistically significant (p = 0.232 for histological inflammation; p = 0.376 for neutrophil count). Conclusion. Administration of Lactobacillus plantarum IS-10506 was associated with a reduction in histopathological lung inflammation and neutrophilic infiltration in mice following smoke inhalation, though the findings did not reach statistical significance.