Improvement in sleep following treatment initiation in newly diagnosed, treatment-naïve patients with Wilson’s disease

Sleep disturbances (SD) are common in chronic liver diseases and neurodegenerative disorders, including Wilson's disease (WD). However, there is limited evidence regarding improvement in sleep quality following initiation of anti-copper therapy in treatment-naïve WD patients. We performed and evaluated video-polysomnography (vPSG) in six newly diagnosed, treatment-naïve WD patients. All patients underwent overnight vPSG before and after initiation of anti-copper treatment. None of the patients reported subjective SD during routine clinical assessment. Objective improvement in sleep efficiency (SE) was observed in five patients, with increases of 6.4%, 7.4%, 17.1%re, 17.3%, and 45.6%, respectively. In three patients, SE normalized (> 90%) after treatment. One patient demonstrated a decline in SE on follow-up (73.5% vs. 67.4%). Initiation of anti-copper treatment in newly diagnosed WD patients may lead to improvements in sleep quality, in addition to neurological symptom relief. These preliminary findings warrant confirmation in larger, controlled studies.