Formulation and Evaluation of Rapid Dissolving Tablet of Bilastine

The demand for fast dissolving tablets has been growing during the last decade especially for elderly and children who have swallowing difficulties. In the present work fast dissolving tablets of Bilastine were prepared with Plantago ovata seed powder ,Tulsion 33 and Locust bean gum as superdisintegrants by direct compression method. The tablets were evaluated for various parameters including weight variation , hardness, friability, drug content ,In vitro drug release and FTIR. The tablets prepared by direct compression method had a weight variation in the range of 118.35 to 122.31, hardness of 2.36 to 3.25 Kg/cm2 , percentage friability of 0.33 to 0.52 % is with in the limits, drug content uniformity between 97.21 to 99.83 % and In vitro drug release of B4 formulation was 99.25% for 30mints. The FTIR spectral analysis showed no drug interaction with formulation additives of the tablet and the formulation indicated no significants.