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September 10, 2025Advanced MaterialsOpen Access

Selective Lipolysis by Photoactivation of Chaperone‐Mediated Autophagy Using Adipocyte Membrane‐Coated Nanoparticle in Hydrogel

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This research demonstrates that a novel nanomaterial enhances lipolysis in adipocytes, indicating an innovative approach to obesity treatment.

Selective lipolysis was significantly enhanced through photoactivation of chaperone-mediated autophagy in adipocytes.
Adipocyte membrane-coated nanoparticles demonstrated greater uptake and interaction with adipocytes compared to other cell types.
The treatment led to substantial weight loss in high-fat diet-fed mice, with persistence of therapeutic effects for over 3 days.
This approach may have broader applications in diseases associated with autophagy dysregulation.

Choi et al. (2025) studied this question.

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This research demonstrates that a novel nanomaterial enhances lipolysis in adipocytes, indicating an innovative approach to obesity treatment.