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September 10, 2025Frontiers in PharmacologyOpen Access

Assessment of drug permeability using a small airway microphysiological system

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Authors

RGRobert GeigerGoogle (United States)SRShekh M RahmanCenter for Drug Evaluation and ResearchMRM. S. Rashid RoniUnited States Food and Drug Administration

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Overview

Assessment of drug permeability through a microphysiological system suggests its relevance for inhaled compounds.

Key Points

  • Drug permeability studies showed albuterol sulfate and formoterol fumarate as highly permeable, indicating effective absorption.
  • Primary human lung epithelial cells were cultured for 14 days, promoting differentiation for accurate permeability measurement.
  • The microphysiological system effectively replicated lung features and measured drug behavior, with specific compounds evaluated.
  • Nonspecific binding was minimal for several compounds, while fluticasone furoate displayed significant binding and was excluded.

Cite This Study

Geiger et al. (2025) studied this question.

synapsesocial.com/papers/68c1aac654b1d3bfb60e318dhttps://doi.org/10.3389/fphar.2025.1621775
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