A novel synthesis reveals a 24% yield for (±)-β-eudesmol using copper catalysis and radical cycling, suggesting scalability.
A concise, protecting group-free approach has been developed for the total synthesis of (±)-β-eudesmol (1), completed in four steps with an overall yield of 24%. This synthesis features a copper-catalyzed Michael addition followed by an in situ aldol reaction, and a one-step Fe(III)/Et3SiH-mediated radical cyclization–oxidation sequence that efficiently constructs the eudesmane skeleton. With its operational simplicity and scalability, this strategy provides a valuable platform for the synthesis of structurally related sesquiterpenoid architectures, paving the way for further biological and structural investigations.
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Panigrahi et al. (2025) studied this question.
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