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September 10, 2025American Journal of Clinical Pathology

An immunohistochemical germinal center B-cell dark zone signature identifies Burkitt lymphoma and molecular high-grade B-cell lymphomas

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Authors

XZXiaoxian ZhaoABAlexandra BalmacedaVAVia S Abiera

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Overview

A new immunohistochemistry algorithm identifies Burkitt lymphoma and high-grade B-cell lymphomas, suggesting improved diagnostic accuracy.

Key Points

  • The immunohistochemistry algorithm achieved 91% sensitivity and 100% specificity for distinguishing Burkitt lymphoma.
  • Among 19 DHLs/THLs assessed, 83% cases demonstrated a dark zone signature on immunohistochemistry.
  • The algorithm shows significant correlation with molecular DZ signatures (P = .0011), enhancing diagnostic precision.
  • This method can support Burkitt lymphoma diagnosis and recognize MYC-BCL2 rearrangements in high-grade lymphomas.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/68c1aad354b1d3bfb60e39b8https://doi.org/10.1093/ajcp/aqaf074
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Developing artificial intelligence-based transcriptomic signature for the diagnosis of dark zone lymphoma in patients without MYC gene rearrangement2025
  2. 2Abstract P35: High-grade B-cell lymphomas with 11q aberrations show a dark zone expression profile similar to Burkitt lymphoma but with additional extension towards intermediate germinal center B-cells2024
  3. 3Abstract IA007: Dark zone lymphomas2026
  4. 4The predictive value of immunohistochemistry for MYC, BCL2, and BCL6 in fluorescence in situ hybridization in aggressive mature B-cell lymphomas and re-evaluation according to the 5th edition of the World Health Organization classification: A single-center 9-year experience2026
  5. 5Overlapping Gene Expression and Molecular Features in High-Grade B-Cell Lymphoma2024