In vitro assays measure the impact on hERG and NaV1.5 ion channels, crucial for cardiac health.
In vitro hERG and NaV1.5 cardiotoxicity assays arecrucial for evaluating the potential of new drugs to cause cardiac arrhythmias.These assays involve measuring the effects of compounds on the hERG (human ether-à-go-go-related gene) and NaV1.5 (sodium channel) ion channels, which play vital roles in cardiac repolarization and action potential propagation.
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Nick Lynch (2025) studied this question.
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