Developed pH-sensitive nanoparticles improve drug release in hypoxia, suggesting new approaches for chemotherapy.
Hypoxic tumor microenvironments pose significant barriers to effective chemotherapy. We developed pH-sensitive polymeric nanoparticles capable of releasing doxorubicin selectively in acidic conditions typical of hypoxic tumors. Nanoparticle characterization confirmed size uniformity, pH-responsiveness, and stability. In vitro and in vivo studies demonstrated enhanced cellular uptake, drug release under acidic conditions, and superior tumor growth inhibition compared to free drug formulations. Our platform offers a promising strategy for overcoming hypoxia-associated chemoresistance.
No takes yet. Share an insight, caveat, or question.
Maaroof et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: