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September 10, 2025Journal of Cellular and Molecular MedicineOpen Access

Naringenin Inhibits Cellular Proliferation, Arrests Cell Cycle and Induces Pro‐Apoptotic Autophagy in MCF‐7 Breast Cancer Cells

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Authors

SMSuhail Ahmad MirBBBasharat BhatPSPriti S. Shenoy

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Overview

Study demonstrates naringenin's inhibition of breast cancer cell proliferation and induction of autophagy, suggesting new therapeutic avenues.

Key Points

  • Naringenin significantly inhibits cell proliferation in MCF-7 breast cancer cells, indicating its therapeutic potential.
  • Cell cycle arrest occurs in the S-phase, reducing migration and increasing apoptosis in breast cancer cells.
  • Observational analysis using MTT and colony formation assays confirms naringenin's anti-proliferative effects.
  • The findings support the need for further exploration of naringenin as a novel treatment option in breast cancer.

Cite This Study

Mir et al. (2025) studied this question.

synapsesocial.com/papers/68c1ac0154b1d3bfb60e47d8https://doi.org/10.1111/jcmm.70747
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Naringenin in Preclinical Models of Breast Cancer2026 · 1 citations
  2. 2Naringenin as potent anticancer phytocompound in breast carcinoma: from mechanistic approach to nanoformulations based therapeutics2024 · 22 citations
  3. 3In-Vitro Cytotoxicity, Apoptotic Property, and Gene Expression Changes Induced by Naringenin-7-O-Glucoside in Triple-Negative Breast Cancer2024 · 5 citations
  4. 4Naringenin Induces Cellular Apoptosis in Melanoma Cells<i>via</i>Intracellular ROS Generation2024 · 5 citations
  5. 5Naringenin nanoparticles show anti-angiogenic activity in HUVECs and a chick chorioallantoic membrane model and anticancer activity in MCF-7 cells2025