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September 10, 2025Light Science & ApplicationsOpen Access

Chip-based label-free incoherent super-resolution optical microscopy

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Authors

NJNikhil JayakumarLVLuis E. Villegas-HernándezWZWeisong Zhao

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Overview

This methodology demonstrates label-free imaging in biological samples, circumventing traditional diffraction limits.

Key Points

  • Resolution improvements of 1.9× to 2.8× over the diffraction limit were achieved using the EPSLON technique.
  • The method utilizes photoluminescence for near-field illumination, allowing for optical nanoscale image capture.
  • Incoherent super-resolution imaging was applied to biological samples without the need for labels, enhancing stability.
  • Fourier Ring Correlation validated the two-point resolution of approximately 180 nm on super-resolved nanobeads.

Cite This Study

Jayakumar et al. (2025) studied this question.

synapsesocial.com/papers/68c1ac0954b1d3bfb60e48edhttps://doi.org/10.1038/s41377-025-01914-x
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