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July 11, 2026ACS Photonics

High-Contrast Interferometric Imaging of Single-Molecule Dynamics on Optical Fibers

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Authors

GLG LiXTXiaotian TanGWG Wang

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Overview

Randomized trial investigates high-contrast imaging of single molecules, highlighting methodological advances for diagnostics.

Key Points

  • To observe individual biomolecular events using high-contrast interferometric imaging and improve signal detection.
  • Proposed a label-free approach utilizing interferometric imaging on optical fibers.
  • Maintained strong evanescent fields for near-field illumination.
  • Monitored phase changes and protein dynamics in response to acoustic waves.
  • Achieved approximately 38 dB enhancement in signal-to-noise ratio compared to conventional fluorescence methods.
  • Successfully tracked conformational transitions and binding behaviors of individual protein molecules.
  • Demonstrated miniaturization of an acoustic sensor at the single-molecule scale.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a51e019c18d7f28ca500a4bhttps://doi.org/10.1021/acsphotonics.6c00760
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