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September 10, 2025Frontiers in ImmunologyOpen Access

Mice mucosal leishmaniasis model shown high parasite load, increased cytotoxicity and impaired IL-10+ T cell response

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Authors

ADAlisson Amaral Da-RochaUniversidade Federal do Rio de JaneiroJDJúlio Souza dos-SantosUniversidade Federal do Rio de JaneiroIBIgor Santos BittencourtUniversidade Federal do Rio de Janeiro

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Overview

Observational analysis reveals increased parasite load and impaired IL-10 positive T cell response in BALB/c mice, highlighting significant inflammatory pathways.

Key Points

  • Infection in BALB/c mice led to a significant increase in parasite load and inflammatory responses over 12 weeks.
  • Mice exhibited heightened levels of cytotoxic mediators like CD107 and granzyme B, indicating robust immune activity.
  • The immunopathological model underscores the imbalance between inflammatory and regulatory responses in mucosal leishmaniasis.
  • Findings suggest that the mucosal model provides a valuable framework for studying leishmaniasis pathology and immune dynamics.

Cite This Study

Da-Rocha et al. (2025) studied this question.

synapsesocial.com/papers/68c1ad4f54b1d3bfb60e4e1ahttps://doi.org/10.3389/fimmu.2025.1621781
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