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September 10, 2025Applied Organometallic Chemistry

Design, Synthesis, DFT, and Biological Evaluation of Nano‐Sized Pt(II) and Cu(II) Complexes of 2‐(Benzodoxazol‐2‐yl)phenylphosphoramidic Dichloride: Spectral Analysis, Cell Cycle Arrest, Apoptosis Assay, Cytotoxicity, and DNA Binding/Cleavage

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Authors

NANada D. AlkhathamiDADeemah Mizher AlenazyIMIbtisam Mousa

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Overview

Synthesis and characterization of benzo[d]oxazole complexes show strong cytotoxic effects in cancer cells, indicating potential for further development.

Key Points

  • The Pt(II) complex induces DNA damage in cancer cells, leading to apoptosis and cell cycle arrest.
  • Quantitative assessments reveal that the complexes demonstrate significant cytotoxicity against MCF7 and HePG2 cell lines.
  • Utilizing DFT for structural validation, both Cu(II) and Pt(II) complexes exhibit strong binding affinity to CT-DNA.
  • The synthesized metal complexes act as effective antimicrobial agents against various bacterial and fungal pathogens.

Cite This Study

Alkhathami et al. (2025) studied this question.

synapsesocial.com/papers/68c1ad4f54b1d3bfb60e4f9ahttps://doi.org/10.1002/aoc.70319
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