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September 10, 2025BMC PediatricsOpen Access

Prevalence of liver disorders in children and adolescents with type 1 diabetes mellitus

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Authors

MAMirna AničićKDKatja DumićLMLucija Kolega Mrkic

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Overview

Observational analysis identified liver disorders in 154 children with type 1 diabetes, suggesting glycogenic hepatopathy is common and MRI is valuable.

Key Points

  • Liver disorders were found in children with type 1 diabetes, highlighting their prevalence among this group.
  • A total of 9.7% had hepatomegaly and 18.8% exhibited elevated transaminases, indicating significant liver issues.
  • MRI effectively distinguished between glycogenic hepatopathy and non-alcoholic fatty liver disease, correlating well with biopsy results.
  • Initial screening of liver disorders can be performed using liver enzymes and ultrasound, minimizing the need for invasive procedures.

Cite This Study

Aničić et al. (2025) studied this question.

synapsesocial.com/papers/68c1ad4f54b1d3bfb60e4ff7https://doi.org/10.1186/s12887-025-05914-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ultrasound Findings of Liver and Pancreas in Children with Type 1 Diabetes Mellitus: A Case-Control Study2024
  2. 2Glycogenic Hepatopathy: A Case Report of a Rare Complication in Uncontrolled Diabetes2025
  3. 32105-P: Hepatic Sparing Despite Adiposity in Adolescents with Type 1 Diabetes: MRI-Based Evidence2026
  4. 4Poorly controlled pediatric type 1 diabetes mellitus is a risk factor for metabolic dysfunction associated steatotic liver disease (MASLD): An observational study2024 · 6 citations
  5. 5Features of the Liver Sonoelastography Findings in Patients with Type 1 Diabetes Mellitus in Childhood2024