Diastereoseletive Synthesis of 1,4-Diaryl Piperazines through the Dimerization of 3-Aminooxetanes with a Cooperative Indium-Diphenyl Phosphate Catalysis

Long Cheng; Cuicui Nian; Zhengyu Han; Jianwei Sun; Hai Huang

doi:10.1039/d5cc03616j

January 1, 2025Chemical Communications

Diastereoseletive Synthesis of 1,4-Diaryl Piperazines through the Dimerization of 3-Aminooxetanes with a Cooperative Indium-Diphenyl Phosphate Catalysis

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Key Points

This reaction achieved efficient diastereoselective synthesis of piperazines.
The dimerization reaction effectively utilized indium and diphenyl phosphate catalysts for piperazine formation.
The method demonstrated a successful [3+3] annulation culminating in multiple piperazine derivatives.
Cooperative catalysis might provide new pathways for more complex synthetic applications.

Implication

Catalytic dimerization of 3-aminooxetanes achieved piperazine derivatives, highlighting indium and diphenyl phosphate as effective catalysts.

Abstract

A catalytic dimerization reaction of 3-aminooxetanes has been developed with cooperative indium/diphenyl phosphate catalysis, successfully achieving a [3+3] annulation reaction to provide a series of piperazine derivatives. The reaction features...

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Cite This Study

Cheng et al. (2025) studied this question.

synapsesocial.com/papers/68c1ad5554b1d3bfb60e51d4 https://doi.org/10.1039/d5cc03616j

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Diastereoseletive Synthesis of 1,4-Diaryl Piperazines through the Dimerization of 3-Aminooxetanes with a Cooperative Indium-Diphenyl Phosphate Catalysis

Key Points

Implication

Abstract

Discussion

Cite This Study

Diastereoseletive Synthesis of 1,4-Diaryl Piperazines through the Dimerization of 3-Aminooxetanes with a Cooperative Indium-Diphenyl Phosphate Catalysis

Key Points

Implication

Abstract

Discussion

Cite This Study

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