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Effect of Aspirin Challenge on Innate Lymphoid Cells in Asthma Patients With Aspirin Hypersensitivity

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Blood ILC1 count significantly increases during aspirin-induced bronchospasm in patients with N-ERD.
Prostaglandins and leukotriene levels significantly reduce during bronchospasm in the induced sputum.
Sputum ILC counts remain very low and do not show reliable changes during bronchospasm.
Findings indicate distinct immune response patterns between eosinophilic and noneosinophilic asthma phenotypes.

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Study reveals aspirin-induced bronchospasm impacts blood ILC1 counts in N-ERD asthma patients, suggesting immune response variations.

Kacorzyk et al. (2025) studied this question.

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