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September 10, 2025Medicine International

Downregulation of kinetochore‑associated 1 gene increases lagging chromosomes and contributes to chromosomal instability in gastric cancer cells

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Authors

DODaiki OhsakiKKKazuki Kanayama

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Overview

Observational analysis reveals KNTC1 downregulation increases lagging chromosomes in gastric cancer, suggesting links to chromosomal instability.

Key Points

  • Downregulation of KNTC1 leads to increased lagging chromosomes and chromosomal instability in gastric cancer cell lines.
  • GC cell lines with low KNTC1 expression showed a higher frequency of lagging chromosomes, with significant findings in RTK gene-amplified cells.
  • The KNTC1 gene, crucial for proper chromosome segregation, is associated with aneuploidy and chromosomal instability.
  • Findings suggest KNTC1 suppression contributes to genetic heterogeneity and poor prognosis in gastric cancer.

Cite This Study

Ohsaki et al. (2025) studied this question.

synapsesocial.com/papers/68c1ad5554b1d3bfb60e53bdhttps://doi.org/10.3892/mi.2025.258
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