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September 10, 2025Journal of the American Chemical Society

C(sp3)–H Amination with an Ammonia-Derived Copper(III) Amide

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Authors

MRMaxwell S. Reese JQJoshua A. QueenerThe Ohio State University CMCurtis E. MooreThe Ohio State University

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Implication

Research reports the synthesis of copper complexes that enable efficient C(sp3)-H activation and C(sp3)-N bond formation, suggesting potential applications in organic synthesis.

Key Points

The copper(II) ammine complex has the highest N-H bond strength reported for an M-NH3 species at 92.8 kcal/mol.
Copper(III) amide effectively mediates the conversion of C(sp3)-H bonds to C(sp3)-N bonds, producing various functionalized hydrocarbons.
These findings highlight the potential of ammonia-derived copper complexes in organic synthesis and functionalization.
The research emphasizes the significance of metal-amide complexes in facilitating reactions involving C-H activation.

Cite This Study

Reese et al. (2025) studied this question.

synapsesocial.com/papers/68c1ad5554b1d3bfb60e53c5 https://doi.org/10.1021/jacs.5c09977

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Implication

Research reports the synthesis of copper complexes that enable efficient C(sp3)-H activation and C(sp3)-N bond formation, suggesting potential applications in organic synthesis.

C(sp3)–H Amination with an Ammonia-Derived Copper(III) Amide

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Member takes

Implication

Key Points

Cite This Study

C(sp3)–H Amination with an Ammonia-Derived Copper(III) Amide

Discussion

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Implication

Key Points

Cite This Study

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