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September 10, 2025Organic & Biomolecular Chemistry

Development of novel quinazoline based ATR inhibitors: Implications for DNA damage response in ATM-deficient and ATM-proficient cancer cells

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Quinazoline-based ATR inhibitors effectively target DNA damage response in cancer cells.
In ATM-deficient cancer cells, these inhibitors significantly enhance the therapeutic impact.
Research involved developing novel compounds and analyzing their effects on DNA repair mechanisms.
Targeting ATR could offer new avenues for cancer treatment, especially in specific patient populations.

Implication

Research shows that quinazoline based ATR inhibitors impact DNA damage response in both ATM-deficient and ATM-proficient cancer cells, indicating potential therapeutic implications.

Abstract

Ataxia telangiectasia and rad3-related (ATR) kinase has recently emerged as a promising drug target for cancer treatment. Being the central mediator of replication stress, targeting ATR kinase in cancer provides...

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Cite This Study

Bhagwat et al. (2025) studied this question.

synapsesocial.com/papers/68c1ad5c54b1d3bfb60e543b https://doi.org/10.1039/d5ob00849b

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Implication

Research shows that quinazoline based ATR inhibitors impact DNA damage response in both ATM-deficient and ATM-proficient cancer cells, indicating potential therapeutic implications.

Development of novel quinazoline based ATR inhibitors: Implications for DNA damage response in ATM-deficient and ATM-proficient cancer cells

Key Points

Implication

Abstract

Discussion

Cite This Study

Development of novel quinazoline based ATR inhibitors: Implications for DNA damage response in ATM-deficient and ATM-proficient cancer cells

Key Points

Implication

Abstract

Discussion

Cite This Study

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