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September 10, 2025DiagnosticsOpen Access

Changes in Cardiac Function and Exercise Capacity Following Ferric Carboxymaltose Administration in HFrEF Patients with Iron Deficiency

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Authors

ATAnastasios TsarouchasCBConstantinos BakogiannisDMDimitrios Mouselimis

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Overview

Observational analysis showed enhanced cardiac function and peak VO2 in HFrEF patients after ferric carboxymaltose therapy, implying better exercise capacity.

Key Points

  • Ferric carboxymaltose significantly improved left ventricular ejection fraction and exercise capacity.
  • LVEF increased from 29.3% to 32.5%, while peak VO2 rose from 11.3 to 12.1 mL/min/kg.
  • Echocardiographic indices demonstrated improved cardiac function, correlating positively with exercise capacity.
  • HFrEF patients with iron deficiency showed promising responses to ferric carboxymaltose treatment over 12 months.

Cite This Study

Tsarouchas et al. (2025) studied this question.

synapsesocial.com/papers/68c1ad6354b1d3bfb60e591chttps://doi.org/10.3390/diagnostics15151941
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ferric Carboxymaltose Therapy Improves the Index of Cardiac Electrophysiological Balance in Iron-Deficient Heart Failure with Reduced Ejection Fraction2026
  2. 2The effect of intravenous ferric carboxymaltose on right ventricular function – insights from the IRON‐CRT trial2022 · 19 citations
  3. 3Influence of intravenous ferric carboxymaltose on non-invasive parameters of left ventricular myocardial work in patients with heart failure with reduced ejection fraction2022 · 2 citations
  4. 4Intravenous ferric carboxymaltose in patients with heart failure and iron deficiency: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis2026
  5. 5Improvement in Left Atrial Strain Following Ferric Carboxymaltose in Heart Failure: An Analysis of the Myocardial-IRON Trial2023 · 7 citations