A Study to Assess the Correlation of Ft3, Ft4 and Ultrasensitive TSH With Severity of Liver Dysfunction According to Child Pugh Score in Cirrhotic Patients

Background:Cirrhosis affects multiple physiological systems, including thyroid hormone regulation. This study explores the association between thyroid hormone levels and liver dysfunction severity. Objective: To assess the correlation of free triiodothyronine (FT3), free thyroxine (FT4), and ultrasensitive thyroid-stimulating hormone (US-TSH) with liver dysfunction in cirrhotic patients, using the Child-Pugh classification. Methods: Eighty cirrhotic patients were categorized into Child-Pugh classes A, B, and C. Serum levels of FT3, FT4, and US-TSH were measured and analyzed in relation to disease severity. Results: FT3 levels significantly declined with worsening Child-Pugh class. FT4 and US-TSH levels showed variable patterns, possibly indicating adaptive physiological responses. Conclusion: Thyroid hormone alterations, particularly reduced FT3 levels, are associated with advanced liver dysfunction. Routine thyroid function testing in cirrhotic patients may offer additional clinical insight. Further research is needed to clarify the prognostic value of these hormonal changes.