Trichilemmal Keratinized Lesion of the Upper Palpebral Conjunctiva: A Case Report

To present a case of keratinized lesion of the upper palpebral conjunctiva in a patient without prior ocular or systemic history. A case of keratinized lesion located at the upper palpebral conjunctiva in a 21-year-old female patient was managed at the Department of Ophthalmology of the University Hospital of Heraklion. Comprehensive clinical assessments, surgical excision, histopathological examinations, and relevant investigations were conducted to characterize the lesion and identify clinical and histological features. The patient was followed up for 12 months postoperatively. Major presenting symptoms were ocular discomfort and conjunctival hyperemia. Histopathological examination was compatible with a cystic lesion with trichilemmal keratinization. No recurrence was observed during the follow-up period. Conclusions: Focal keratinization of diverse pathogenetic origin and histological appearance at the epithelium of the upper palpebral conjunctiva can be found in young patients without a previous history of trauma, surgery, or inflammation.