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This method detects phenylpropanolamine concentrations in human urine, revealing implications for forensic toxicology.
Phenylpropanolamine hydrochloride (PPA) is a stimulant commonly found in some over-thecounter decongestants and appetite suppressants, but its misuse and potential health risks necessitate reliable forensic detection methods. This study aims to develop and validate a UV-Vis spectrophotometric method for the quantitative analysis of PPAin human urine samples. The method involves determining the maximum absorption wavelength (λmax) of PPAstandard and measuring the absorbance of urine samples at this wavelength. Calibration curves were constructed using standard solutions of PPA, resulting in a strong linear relationship with a correlation coefficient (r) of 0.9989 and a regression equation of y = 0,0528x + 0,0145. Urine samples from consumers were analyzed, revealing a PPAconcentration of 10.59 μg/mL. The presence of chromophore groups in the benzene ring of PPAfacilitates ultraviolet light absorption, allowing sensitive detection by UV spectroscopy. The proposed method demonstrated high accuracy, precision, and rapid analysis capability, making it suitable for forensic toxicology applications. The quantification of PPAin urine provides valuable information for monitoring drug intake, supporting legal investigations, and ensuring public safety. In conclusion, UV-Vis spectrophotometry offers a reliable, cost-effective, and non-destructive technique for the forensic analysis of PPAin biological fluids, contributing significantly to the field of forensic chemistry.
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Taufik et al. (2025) studied this question.
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