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January 1, 2025RSC Medicinal ChemistryOpen Access

Integrated in silico and experimental screening identifies novel ligands that target precursor microRNA-31 at the Dicer cleavage site.

Grace Arhin Lily Haghpassand Sarah C. Keane

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Key Points

Identification of new ligands shows promise for targeting precursor microrna-31 and regulating gene expression.
In silico and experimental methods revealed novel interactions with the Dicer cleavage site, enhancing potential therapies.
The study utilizes combined computational and experimental approaches, ensuring comprehensive screening of ligands.
These findings may contribute to developing new treatments for diseases associated with microrna dysregulation.

Implication

Integrated screening identifies novel ligands that impact microrna regulation, highlighting their potential therapeutic roles.

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Cite This Study

Arhin et al. (2025) studied this question.

synapsesocial.com/papers/68c1afb954b1d3bfb60e728e https://doi.org/10.1039/d5md00553a

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