Integrated transcriptomic and metabolomic analyses to decipher the regulatory mechanisms of polystyrene nanoplastic-induced metabolic disorders in hepatocytes

Yuting Fang; Yukang Zhang; Tingting Wei; Huraira Akhtar; Yuqing Song; Yajie Wang; Man Yang; Rongzhang Hao; Yanbo Li; Zhiwei Sun; Ji Wang

doi:10.1039/d5en00161g

January 1, 2025Environmental Science Nano

Integrated transcriptomic and metabolomic analyses to decipher the regulatory mechanisms of polystyrene nanoplastic-induced metabolic disorders in hepatocytes

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Key Points

Polystyrene nanoplastics disrupt hepatocyte metabolism, impacting lipid and amino acid pathways affecting health.
Key genes were identified through a comprehensive integrated omics approach, shedding light on metabolic disorders.
The study utilized transcriptomic and metabolomic analyses to understand the effects of nanoplastics on liver cells.
Findings may inform health risk assessments regarding micro and nanoplastic exposure in humans.

Implication

Integrated omics approach reveals disrupted lipid and amino acid metabolism in hepatocytes, indicating health risks from polystyrene nanoplastics.

Abstract

This study reveals that PSNPs disrupt hepatocyte lipid and amino acid metabolism and identifies key genes using an integrated omics approach. It provides data for understanding MNP hazards and assessing health risks.

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Cite This Study

Fang et al. (2025) studied this question.

synapsesocial.com/papers/68c1afb954b1d3bfb60e7346 https://doi.org/10.1039/d5en00161g

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Integrated transcriptomic and metabolomic analyses to decipher the regulatory mechanisms of polystyrene nanoplastic-induced metabolic disorders in hepatocytes

Key Points

Implication

Abstract

Discussion

Cite This Study

Integrated transcriptomic and metabolomic analyses to decipher the regulatory mechanisms of polystyrene nanoplastic-induced metabolic disorders in hepatocytes

Key Points

Implication

Abstract

Discussion

Cite This Study

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