Among the various routes of administration oral route is the most commonly used, due to availability of large surface area for absorption and ease of administration targeting a drug to a particular organ or tissue and regulating the pace of drug delivery to the target site can be made much easier with the aid of a well-designed controlled release drug delivery system. Because formulation scientists are unable to confine and localize the system at specific parts of the gastrointestinal tract, developing an oral controlled release system has proven to be difficult. A fascinating and intriguing alternative for creating an oral controlled release system is the matrix or reservoir type of drug delivery system. A large range of polymers are readily available, and formulation scientists can create products with controlled or sustained release by using regular dosing intervals.
Ghule et al. (2025) studied this question.