Case study shows overlap of monogenic lupus and autoinflammatory disorders, highlighting interferonopathies' roles.
Monogenic lupus is a highly complex condition with marked variability, resulting from diverse immune system etiopathogenesis linked to various pathogenic genetic variants. There is substantial overlap with newly described systemic autoinflammatory disorders. We present two cases of monogenic lupus and highlight the intersection between monogenic lupus and autoinflammatory disorders. This report emphasizes the concept of monogenic interferonopathies as an umbrella term for various conditions arising from genetic aberrations in type I interferon (IFN-I) signaling, which are associated with significant IFN-I activation.
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Al‐Mayouf et al. (2025) studied this question.
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