Peculiarities of choice of dosing regimen and administration of antibacterial drugs in obese patients

Obesity poses a particular challenge in the selection of drug therapy, requiring special attention to the dosing of drugs, including antibacterial drugs. Pharmacokinetic and pharmacodynamic parameters in obese patients may differ significantly from those in the general population, which affects the efficacy and safety of antibiotic therapy. The purpose of this review is to analyze current data on antibiotic dosing in obese patients to optimize clinical practice and improve treatment outcomes. The study includes an analysis of current scientific publications, clinical guidelines, and pharmacokinetic data regarding the use of antibiotics in obese patients. Particular attention is paid to changes in distribution volume, clearance, and dose adjustment depending on body mass index and other metabolic changes associated with obesity.