Primary sclerosing cholangitis. A clinical case

A clinical case of an 18-year-old patient with primary sclerosing cholangitis, observed from 2021 to 2025, was analyzed. Condition after retrograde bile duct endoprosthetics, laparoscopic cholecystectomy. In 2021, after a new coronavirus infection, the level of total bilirubin, ALAT, GGT and ALP activity increased for the first time. After examination, the following diagnosis was made: Cholestatic hepatitis with a moderate degree of activity against the background of stenosis of the common bile duct. Cholangitis. Biliary sludge. Symptomatic therapy was prescribed. A year later, the condition was unchanged. Retrograde endoprosthetics of the bile ducts was performed, after which the condition improved, the biochemical parameters returned to normal. After 3 months, the stent was removed using a loop. An increase in GGT levels was noted again. A puncture biopsy was performed. Histologically: The degree of fibrosis according to the METAVIR scale is F3. The diagnosis was made: Chronic cholangitis. Condition after stenting. Most likely, the onset of primary sclerosing cholangitis (PSC). A year later, the diagnosis was made: Chronic active hepatitis. Primary sclerosing cholangitis, fibrosis stage F3 according to the METAVIR scale. Therapy was prescribed. The patient is currently under observation and treatment.