This work demonstrates the synthesis of NeuGal analogs using α-selective sialylation, suggesting potential applications in biological studies.
A streamlined synthesis of sialylgalactose (NeuGal) analogs is described. Neuα(2,6)Gal and Neuα(2,3)Gal units were synthesized via fully α-selective sialylation of suitable Gal acceptors using a bicyclic sialyl donor. NeuGals were diversified through C5 amino group modification and sulfation, yielding NeuGal analogs with an amino linker for biological studies.
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Ogawa et al. (2025) studied this question.
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