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September 10, 2025Virology JournalOpen Access

Variation in HIV-1 Tat and Vpr protein amino acid sequences and its association with vascular health measures in a South African cohort: an exploratory study

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Authors

EVEsmé Jansen van VurenYBYolandi BreetAJAdriaan Jacobs

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Overview

Exploratory study shows association of Tat and Vpr amino acid variants with arterial stiffness, suggesting implications for cardiovascular health.

Key Points

  • Variation in HIV-1 Tat protein sequences is associated with increased arterial stiffness markers.
  • Tat and Vpr amino acid sequence variations did not predict hypertension over a five-year period.
  • A cohort of 60 treatment-naïve participants from South Africa was analyzed for vascular health measures.
  • Findings suggest that Tat and Vpr variants may highlight cardiovascular disease mechanisms in PLHIV.

Cite This Study

Vuren et al. (2025) studied this question.

synapsesocial.com/papers/68c1b18554b1d3bfb60e82d1https://doi.org/10.1186/s12985-025-02891-8
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