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Comparative Efficacy of Topical Tofacitinib versus Topical Tacrolimus in the Treatment of localized Vitiligo: A Randomized, Investigator-Blinded, Intraindividual Trial

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Randomized trial compares the effects of topical tofacitinib and tacrolimus in localized vitiligo, highlighting efficacy and tolerability.

Topical tofacitinib achieved treatment success in 46.7% of patches, while tacrolimus succeeded in 36.7%.
Median time to treatment success was shorter with tofacitinib at 8 weeks compared to 12 weeks for tacrolimus.
The study involved a randomized, investigator-blinded trial over 16 weeks with 30 participants and 60 vitiligo patches.
Topical tofacitinib shows promise for vitiligo treatment, with fewer adverse effects than tacrolimus.

Mehta et al. (2025) studied this question.

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Randomized trial compares the effects of topical tofacitinib and tacrolimus in localized vitiligo, highlighting efficacy and tolerability.