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September 10, 2025ChemistrySelect

Antinociceptive and Central Nervous System Depressant Effects of Grewia serrulata Leaf Extracts Through In Vivo and In Silico Investigations

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Authors

MHMd. Anamul HaqueMMMd. Golam MortuzaJSJinat Fatema Sharna

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Overview

In vivo and in silico investigations demonstrate analgesic and CNS depressant effects of Grewia serrulata extracts, suggesting therapeutic potential for pain relief.

Key Points

  • The dichloromethane extract of Grewia serrulata reduced abdominal writhing by 72.16%, showcasing significant analgesic activity.
  • Petroleum ether extract inhibited 77.57% in the head dip test, illustrating strong CNS depressant effects at 100 mg/kg dose.
  • Molecular docking revealed high binding affinity with COX-II and GABA receptors, suggesting effective interactions for pain relief.
  • ADMET analysis indicates promising pharmacokinetic properties, highlighting the therapeutic potential of Grewia serrulata extracts.

Cite This Study

Haque et al. (2025) studied this question.

synapsesocial.com/papers/68c1b18554b1d3bfb60e865ehttps://doi.org/10.1002/slct.202405909
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