Nine ruthenium complexes demonstrate effective synergy in NIR-II therapies for drug-resistant cancer, suggesting new treatment strategies.
Nine nonemissive Ru(II) complexes have been designed for synergistic NIR-II (1064 nm) photodynamic, photothermal, sonodynamic, and sonothermal therapy targeting cisplatin-resistant nonsmall cell lung cancer. Their quantum yields of singlet oxygen and superoxide anions are significantly elevated under low-power NIR-II laser irradiation or ultrasound treatment. The selected complex RY7 completely eradicated drug-resistant lung cancer tumors in all tested mice when treated simultaneously with NIR-II laser and ultrasound at a minimal drug dosage in vivo and was promptly eliminated from the organism. The application of a single-molecule sensitizer to achieve synergistic NIR-II photodynamic/photothermal/sonodynamic/sonothermal therapy may provide important insights into the treatment of deeply located tumors, tackling tumor hypoxia and addressing the complicated pharmacological mechanisms underlying drug resistance. The two-photon absorption quantum chemical calculations presented in this study may also serve as a powerful tool for the rational design and structure-activity relationship studies of two-photon photosensitizers and optical materials.
No takes yet. Share an insight, caveat, or question.
Song et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: