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September 10, 2025AJP Cell Physiology

Diet-Induced Obesity Disrupts Sexually Dimorphic Gene Expression in Mice

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Authors

VRVicent RibasSMSamantha Morón‐RosHMHelena Marí

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Overview

Analysis reveals metabolic dysfunction effects from diet-induced obesity in male and female mice, suggesting critical gene role.

Key Points

  • HFD-fed males showed more severe metabolic impairments than females despite similar adiposity.
  • Significant downregulation of male-biased genes was observed in male WAT under HFD conditions.
  • Whole transcriptomic profiling revealed marked sex-specific gene expression changes during obesity.
  • A considerable portion of sex-biased genes underwent modulation due to HFD exposure, correlating with metabolic health.

Cite This Study

Ribas et al. (2025) studied this question.

synapsesocial.com/papers/68c1b19354b1d3bfb60e8bc8https://doi.org/10.1152/ajpcell.00098.2025
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