Wide-Field Imaging of Brain Tissue Stiffness and Tumour Proxies with Scattered Light

Philip Binner; Jack Radford; M. D. Madhusudan; Ewan J. McGhee; Ilya Starshynov; Gonzalo S. Tejeda; Andrew B. Tobin; Jinendra Ekanayake; Daniele Faccio

doi:10.1364/brain.2025.bth3a.3

January 1, 2025

Wide-Field Imaging of Brain Tissue Stiffness and Tumour Proxies with Scattered Light

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Key Points

Local tissue stiffness anomalies were detected that were not visible with traditional intensity imaging.
Using laser speckle-based approaches, the study found novel ways to measure tissue stiffness in brain samples.
Wide-field imaging techniques improve the visualization of tumor proxies in fresh mouse brain samples.
This method may enhance the assessment of brain pathologies by revealing stiffness variations undetected by standard imaging.

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Implication

This observational analysis measures tissue stiffness in mouse brain samples, indicating enhanced imaging for detecting tumor proxies.

Abstract

We propose wide-field imaging of tissue stiffness using laser speckle-based approaches. We measure local tissue stiffness anomalies in fresh mouse brain samples that are not visible by intensity imaging.

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Binner et al. (2025) studied this question.

synapsesocial.com/papers/68c1b19354b1d3bfb60e8c0b https://doi.org/10.1364/brain.2025.bth3a.3

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Wide-Field Imaging of Brain Tissue Stiffness and Tumour Proxies with Scattered Light

Key Points

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Abstract

Discussion

Cite This Study

Wide-Field Imaging of Brain Tissue Stiffness and Tumour Proxies with Scattered Light

Key Points

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Implication

Abstract

Discussion

Cite This Study

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