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September 10, 2025RSC AdvancesOpen Access

Investigation for the easy and efficient synthesis of 1H-benzo[d][1,3]oxazine-2,4-diones

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The synthesis produced 1H-benzo[d][1,3]oxazine-2,4-diones efficiently using various carbonyloxy groups.
Results indicate effective utilization of 2-aminobenzoic acids, with key methods involving fluorene derivatives.
Methods included thionyl chloride for activating the carbonyloxy source in the reaction.
This approach highlights novel strategies for synthesizing complex organic compounds efficiently.

Implication

Synthesis utilizes fluorenylmethyloxycarbonyl and thionyl chloride to generate 1H-benzo[d][1,3]oxazine-2,4-diones, suggesting an efficient method for organic synthesis.

Abstract

We report the synthesis of 1 H -benzo[ d ][1,3]oxazine-2,4-diones from 2-aminobenzoic acids, using fluorenylmethyloxycarbonyl (Fmoc), benzyloxycarbonyl (Cbz) and ethyloxycarbonyl (EtOCO) groups as the source of carbonyloxy group, and thionyl chloride.

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Cite This Study

Mitsostergios et al. (2025) studied this question.

synapsesocial.com/papers/68c1b19954b1d3bfb60e8e05 https://doi.org/10.1039/d5ra04014k

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Implication

Synthesis utilizes fluorenylmethyloxycarbonyl and thionyl chloride to generate 1H-benzo[d][1,3]oxazine-2,4-diones, suggesting an efficient method for organic synthesis.

Investigation for the easy and efficient synthesis of 1H-benzo[d][1,3]oxazine-2,4-diones

Key Points

Implication

Abstract

Discussion

Cite This Study

Investigation for the easy and efficient synthesis of 1H-benzo[d][1,3]oxazine-2,4-diones

Key Points

Implication

Abstract

Discussion

Cite This Study

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