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September 10, 2025SciOpen Access

The Response of Cell Cultures to Nutrient- and Serum-Induced Changes in the Medium

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Authors

MJMarijana JukićUniversity of Osijek KŠKatarina Mišković ŠpoljarićUniversity of Osijek KVKarla VojvodićUniversity of Osijek

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Implication

This study investigates how glucose and fetal bovine serum impact mitochondrial function and autophagy in various cell lines, highlighting implications for cancer research.

Key Points

High glucose conditions increase mitochondrial activity in HeLa and SW-620 cells, while low glucose reduces ATP content in HeLa.
MRC-5 fibroblasts and Caco-2 cells show remarkable resilience to nutrient stress with minimal LDH release variations.
Autophagy is activated in all conditions, with significant increases in select cell-medium combinations enhancing cellular responses.
The composition of the culture medium significantly influences bioenergetics and stress responses, relevant for metabolic disease modeling.

Cite This Study

Jukić et al. (2025) studied this question.

synapsesocial.com/papers/68c1b19954b1d3bfb60e8f91 https://doi.org/10.3390/sci7030105

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Implication

This study investigates how glucose and fetal bovine serum impact mitochondrial function and autophagy in various cell lines, highlighting implications for cancer research.

The Response of Cell Cultures to Nutrient- and Serum-Induced Changes in the Medium

Discussion

Member takes

Implication

Key Points

Cite This Study

The Response of Cell Cultures to Nutrient- and Serum-Induced Changes in the Medium

Discussion

Member takes

Implication

Key Points

Cite This Study

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