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September 10, 2025Journal of Diabetes InvestigationOpen Access

Research on the characteristics of gut microbiota in overweight patients with early‐onset type 2 diabetes mellitus

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Authors

KHKe HuangSichuan University LMLeilei MaHebei Medical University SSShousen ShiChina Jiliang University

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Implication

This observational study finds gut microbiota differences in overweight patients with early-onset type 2 diabetes, suggesting potential microbial biomarkers.

Key Points

Significant differences in gut microbiota composition were identified between overweight patients with early-onset type 2 diabetes and healthy controls.
The results showed an increased ratio of Firmicutes/Bacteroidetes in EOD patients, with specific genera such as Bilophila enriched and Clostridia_UCG-014 depleted.
Correlation analyses highlighted negative associations of Clostridia_UCG-014 with obesity markers like body mass index and fasting plasma glucose.
The findings underscore Bilophila and Clostridia_UCG-014's potential as microbial biomarkers for identifying obesity-related early-onset type 2 diabetes.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68c1b1a154b1d3bfb60e93c4 https://doi.org/10.1111/jdi.70074

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Implication

This observational study finds gut microbiota differences in overweight patients with early-onset type 2 diabetes, suggesting potential microbial biomarkers.

Research on the characteristics of gut microbiota in overweight patients with early‐onset type 2 diabetes mellitus

Discussion

Member takes

Implication

Key Points

Cite This Study

Research on the characteristics of gut microbiota in overweight patients with early‐onset type 2 diabetes mellitus

Discussion

Member takes

Implication

Key Points

Cite This Study

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